BRCA1 and BRCA2 are the well known genes associated with the development of breast cancer.
They are tumor-suppressor genes (just as it states, these genes suppress tumor growth) that produce proteins to help repair damaged DNA.
If these genes get mutated or damaged, they fail to produce the right proteins, and the DNA may not be repaired. This can lead to more mutations and, eventually, the development of cancer. According to the Journal of Epidemiology Community Health, ‘Genetic inheritance is an infrequent but not the main cause of breast cancer.
The consensus is that breast cancer susceptibility or cancer predisposition genes are associated with only 4%–8% of breast cancer cases.
It is apparent therefore that 92%–96% of cases are sporadic.
The New England Journal of Medicine states that only 7% of women from families with a history of breast cancer had BRCA1 mutations.
Last, the journal Carcinogenesis states that mutations of the BRCA1 and BRCA2 genes account for 5% of breast cancer in the US annually.
Pharmaceutical Research published an article titled “Cancer Is a Preventable Disease That Requires Major Lifestyle Changes.” The article starts by saying that scientists believe that the majority of cancer cases are preventable.
The research goes on to say that 90 to 95 percent of all cases are rooted in the environment and lifestyle.
In other words, if you are eating a processed, nutrient-deprived diet, are sedentary, have excessive body fat, or are inhaling and drinking toxins, you are creating an environment for the growth of cancer.
O’Donovan P, and Livingston D. BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis vol.31 no.6 pp.961–967, 2010
Wiseman R. Breast cancer hypothesis: a single cause for the majority of cases. Journal of Epidemiology & Community Health 2000;54:851–858
Preetha Anand, Ajaikumar B. Kunnumakara, Chitra Sundaram, Kuzhuvelil B. Harikumar, Sheeja T. Tharakan, Oiki S. Lai, Bokyung Sung, and Bharat B. Aggarwal. Cancer Is a Preventable Disease That Requires Major Lifestyle Changes. Pharmaceutical Research, 2008; 25; 9.